List of Published Papers

Current Ongoing Studies Using GlycoCheck and Endocalyx

Most Recent Published Papers Using GlycoCheck

Functional capillary impairment in patients with ventricular assist devices.
Sci Rep. 2019 Apr 11;9(1):5909. doi: 10.1038/s41598-019-42334-3.

Early Onset Preeclampsia Is Associated With Glycocalyx Degradation and Reduced Microvascular Perfusion.
J Am Heart Assoc. 2019 Feb 19;8(4):e010647. doi: 10.1161/JAHA.118.010647.

Alterations of conjunctival glycocalyx and microcirculation in non-septic critically ill patients
Microvasc Res. 2018 Jul;118:44-48. doi: 10.1016/j.mvr.2018.02.004. Epub 2018 Feb 17.

Automated Measurement of Microvascular Function Reveals Dysfunction in Systemic Sclerosis: A Cross-sectional Study.
J Rheumatol. 2017 Nov;44(11):1603-1611. doi: 10.3899/jrheum.170120. Epub 2017 Sep 15.

Advanced age results in a diminished endothelial glycocalyx.
Am J Physiol Heart Circ Physiol. 2018 Sep 1;315(3):H531-H539. doi: 10.1152/ajpheart.00104.2018. Epub 2018 May 11.

Induced Trf2 deletion leads to aging vascular phenotype in mice associated with arterial telomere uncapping, senescence signaling, and oxidative stress.
J Mol Cell Cardiol. 2019 Feb;127:74-82. doi: 10.1016/j.yjmcc.2018.11.014. Epub 2018 Nov 29.

Impact of Intravenous Fluid Challenge Infusion Time on Macrocirculation and Endothelial Glycocalyx in Surgical and Critically Ill Patients.
Biomed Res Int. 2018 Nov 1;2018:8925345. doi: 10.1155/2018/8925345. eCollection 2018.

Neuraxial anesthesia is less harmful to the endothelial glycocalyx during elective joint surgery compared to general anesthesia1,2.
Clin Hemorheol Microcirc. 2018 Nov 29. doi: 10.3233/CH-180428. [Epub ahead of print]

Effect of acute hypernatremia induced by hypertonic saline administration on endothelial glycocalyx in rabbits.
Clin Hemorheol Microcirc. 2018 Nov 2. doi: 10.3233/CH-189907. [Epub ahead of print]

The Effect of Fluid Loading and Hypertonic Saline Solution on Cortical Cerebral Microcirculation and Glycocalyx Integrity.
J Neurosurg Anesthesiol. 2018 Jul 13. doi: 10.1097/ANA.0000000000000528. [Epub ahead of print]

Increase in perfused boundary region of endothelial glycocalyx is associated with higher prevalence of ischemic heart disease and lesions of microcirculation and vascular wall.
Microcirculation. 2018 May;25(4):e12454. doi: 10.1111/micc.12454.

In vivo assessment of the human cerebral microcirculation and its glycocalyx: A technical report.
J Neurosci Methods. 2018 Jun 1;303:114-125. doi: 10.1016/j.jneumeth.2018.03.009. Epub 2018 Mar 22.

HDL cholesterol levels and endothelial glycocalyx integrity in treated hypertensive patients.
J Clin Hypertens (Greenwich). 2018 Nov;20(11):1615-1623. doi: 10.1111/jch.13404. Epub 2018 Oct 13.

Association of impaired endothelial glycocalyx with arterial stiffness, coronary microcirculatory dysfunction, and abnormal myocardial deformation in untreated hypertensives.
J Clin Hypertens (Greenwich). 2018 Apr;20(4):672-679. doi: 10.1111/jch.13236. Epub 2018 Mar 2.

Sublingual functional capillary rarefaction in chronic heart failure.
Eur J Clin Invest. 2018 Feb;48(2). doi: 10.1111/eci.12869. Epub 2017 Dec 14.

Bedside analysis of the sublingual microvascular glycocalyx in the emergency room and intensive care unit - the GlycoNurse study.
Scand J Trauma Resusc Emerg Med. 2018 Feb 14;26(1):16. doi: 10.1186/s13049-018-0483-4.

Functional capillary impairment in patients with ventricular assist devices.
Sci Rep. 2019 Apr 11;9(1):5909. doi: 10.1038/s41598-019-42334-3.

Early Onset Preeclampsia Is Associated With Glycocalyx Degradation and Reduced Microvascular Perfusion.
J Am Heart Assoc. 2019 Feb 19;8(4):e010647. doi: 10.1161/JAHA.118.010647.

Alterations of conjunctival glycocalyx and microcirculation in non-septic critically ill patients
Microvasc Res. 2018 Jul;118:44-48. doi: 10.1016/j.mvr.2018.02.004. Epub 2018 Feb 17.

Automated Measurement of Microvascular Function Reveals Dysfunction in Systemic Sclerosis: A Cross-sectional Study.
J Rheumatol. 2017 Nov;44(11):1603-1611. doi: 10.3899/jrheum.170120. Epub 2017 Sep 15.

Advanced age results in a diminished endothelial glycocalyx.
Am J Physiol Heart Circ Physiol. 2018 Sep 1;315(3):H531-H539. doi: 10.1152/ajpheart.00104.2018. Epub 2018 May 11.

Induced Trf2 deletion leads to aging vascular phenotype in mice associated with arterial telomere uncapping, senescence signaling, and oxidative stress.
J Mol Cell Cardiol. 2019 Feb;127:74-82. doi: 10.1016/j.yjmcc.2018.11.014. Epub 2018 Nov 29.

Impact of Intravenous Fluid Challenge Infusion Time on Macrocirculation and Endothelial Glycocalyx in Surgical and Critically Ill Patients.
Biomed Res Int. 2018 Nov 1;2018:8925345. doi: 10.1155/2018/8925345. eCollection 2018.

Neuraxial anesthesia is less harmful to the endothelial glycocalyx during elective joint surgery compared to general anesthesia1,2.
Clin Hemorheol Microcirc. 2018 Nov 29. doi: 10.3233/CH-180428. [Epub ahead of print]

Effect of acute hypernatremia induced by hypertonic saline administration on endothelial glycocalyx in rabbits.
Clin Hemorheol Microcirc. 2018 Nov 2. doi: 10.3233/CH-189907. [Epub ahead of print]

The Effect of Fluid Loading and Hypertonic Saline Solution on Cortical Cerebral Microcirculation and Glycocalyx Integrity.
J Neurosurg Anesthesiol. 2018 Jul 13. doi: 10.1097/ANA.0000000000000528. [Epub ahead of print]

Increase in perfused boundary region of endothelial glycocalyx is associated with higher prevalence of ischemic heart disease and lesions of microcirculation and vascular wall.
Microcirculation. 2018 May;25(4):e12454. doi: 10.1111/micc.12454.

In vivo assessment of the human cerebral microcirculation and its glycocalyx: A technical report.
J Neurosci Methods. 2018 Jun 1;303:114-125. doi: 10.1016/j.jneumeth.2018.03.009. Epub 2018 Mar 22.

HDL cholesterol levels and endothelial glycocalyx integrity in treated hypertensive patients.
J Clin Hypertens (Greenwich). 2018 Nov;20(11):1615-1623. doi: 10.1111/jch.13404. Epub 2018 Oct 13.

Association of impaired endothelial glycocalyx with arterial stiffness, coronary microcirculatory dysfunction, and abnormal myocardial deformation in untreated hypertensives.
J Clin Hypertens (Greenwich). 2018 Apr;20(4):672-679. doi: 10.1111/jch.13236. Epub 2018 Mar 2.

Sublingual functional capillary rarefaction in chronic heart failure.
Eur J Clin Invest. 2018 Feb;48(2). doi: 10.1111/eci.12869. Epub 2017 Dec 14.

Bedside analysis of the sublingual microvascular glycocalyx in the emergency room and intensive care unit - the GlycoNurse study.
Scand J Trauma Resusc Emerg Med. 2018 Feb 14;26(1):16. doi: 10.1186/s13049-018-0483-4.

The Measurement of the Endothelial Glycocalyx as a New Biomarker of Endothelial Derangement in Systemic Sclerosis: A Challenge for the Future.
J Rheumatol. 2017 Nov;44(11):1572-1574. doi: 10.3899/jrheum.170958. Epub 2017 Nov 1. No abstract available.

Automated Measurement of Microvascular Function Reveals Dysfunction in Systemic Sclerosis: A Cross-sectional Study.
J Rheumatol. 2017 Nov;44(11):1603-1611. doi: 10.3899/jrheum.170120. Epub 2017 Sep 15.

Non-invasive assessment of microvascular dysfunction in patients with microvascular angina.
Int J Cardiol. 2017 Dec 1;248:433-439. doi: 10.1016/j.ijcard.2017.05.010. Epub 2017 Jul 18.

Effects of varenicline and nicotine replacement therapy on arterial elasticity, endothelial glycocalyx and oxidative stress during a 3-month smoking cessation program.
Atherosclerosis. 2017 May 13;262:123-130.

Protocol for intraoperative assessment of the human cerebrovascular glycocalyx.
BMJ Open. 2017 Jan 5;7(1)

Early detection of left ventricular dysfunction in first-degree relatives of diabetic patients by myocardial deformation imaging: The role of endothelial glycocalyx damage.
Int J Cardiol. 2017 Apr 15;233:105-112.

Side-by-Side Alterations in Glycocalyx Thickness and Perfused Microvascular Density During Acute Microcirculatory Alterations in Cardiac Surgery.
Microcirculation. 2016 Jan;23(1):69-74.

Improvement of arterial stiffness and myocardial deformation in patients with poorly controlled diabetes mellitus type 2 after optimization of antidiabetic medication.
Eur Heart J Cardiovasc Imaging. 2016 Dec 1;17(suppl_2)

The impact of periodontal disease treatment on endothelium of sublingual microvessels.
Stomatologiia (Mosk). 2016;95(4):9-12. Russian.

Perturbation of the microvascular glycocalyx and perfusion in infants after cardiopulmonary bypass.
J Thorac Cardiovasc Surg. 2015 Dec;150(6):1474-81.

Plasma free hemoglobin and microcirculatory response to fresh or old blood transfusions in sepsis.
PLoS One. 2015 May 1;10(5):e0122655

Characteristics and determinants of the sublingual microcirculation in populations of different ethnicity.
Hypertension. 2015 May;65(5):993-1001

Effects of ultrapure hemodialysis and low molecular weight heparin on the endothelial surface layer.
Blood Purif. 2014;38(3-4):203-10

Is the systemic microvascular endothelial glycocalyx in peritoneal dialysis patients related to peritoneal transport?
Nephron ClinPract. 2014;128(1-2):159-65

Deeper penetration of erythrocytes into the endothelial glycocalyx is associated with impaired microvascular perfusion.
PLoS One. 2014 May 9;9(5):e96477

Skeletal muscle capillary density and microvascular function are compromised with aging and type 2 diabetes.
J ApplPhysiol (1985). 2014 Apr 15;116(8):998-1005 

Microcirculatory effects of the transfusion of leukodepleted or non-leukodepleted red blood cells in patients with sepsis: a pilot study.
Crit Care. 2014 Feb 17;18(1):R33

Association of kidney function with changes in the endothelial surface layer.
Clin J Am SocNephrol. 2014 Apr;9(4):698-704

Alteration of the sublingual microvascular glycocalyx in critically ill patients.
Microvasc Res. 2013 Nov;90:86-9

Non-invasive assessment of microvascular dysfunction in families with premature coronary artery disease.
Int J Cardiol. 2013 Oct 12;168(5):5026-8

Sublingual microvascular glycocalyx dimensions in lacunar stroke patients.
Cerebrovasc Dis. 2013;35(5):451-4

Damage of the endothelial glycocalyx in dialysis patients.
J Am SocNephrol. 2012 Nov;23(11):1900-8

Methods for evaluating endothelial function: a position statement from the European Society of Cardiology Working Group on Peripheral Circulation.
Eur J Cardiovasc PrevRehabil. 2011 Dec;18(6):775-89

Effect of sulodexide on endothelial glycocalyx and vascular permeability in patients with type 2 diabetes mellitus.
Diabetologia. 2010 Dec;53(12):2646-55

Acute ischemic injury to the renal microvasculature in human kidney transplantation.
Am J Physiol Renal Physiol. 2010 Nov;299(5):F1134-40

Effects of varenicline and nicotine replacement therapy on arterial elasticity, endothelial glycocalyx and oxidative stress during a 3-month smoking cessation program.
Atherosclerosis. 2017 May 13;262:123-130.

Protocol for intraoperative assessment of the human cerebrovascular glycocalyx.
BMJ Open. 2017 Jan 5;7(1)

Early detection of left ventricular dysfunction in first-degree relatives of diabetic patients by myocardial deformation imaging: The role of endothelial glycocalyx damage.
Int J Cardiol. 2017 Apr 15;233:105-112.

Side-by-Side Alterations in Glycocalyx Thickness and Perfused Microvascular Density During Acute Microcirculatory Alterations in Cardiac Surgery.
Microcirculation. 2016 Jan;23(1):69-74.

Improvement of arterial stiffness and myocardial deformation in patients with poorly controlled diabetes mellitus type 2 after optimization of antidiabetic medication.
Eur Heart J Cardiovasc Imaging. 2016 Dec 1;17(suppl_2)

The impact of periodontal disease treatment on endothelium of sublingual microvessels.
Stomatologiia (Mosk). 2016;95(4):9-12. Russian.

Perturbation of the microvascular glycocalyx and perfusion in infants after cardiopulmonary bypass.
J Thorac Cardiovasc Surg. 2015 Dec;150(6):1474-81.

Plasma free hemoglobin and microcirculatory response to fresh or old blood transfusions in sepsis.
PLoS One. 2015 May 1;10(5):e0122655

Characteristics and determinants of the sublingual microcirculation in populations of different ethnicity.
Hypertension. 2015 May;65(5):993-1001

Effects of ultrapure hemodialysis and low molecular weight heparin on the endothelial surface layer.
Blood Purif. 2014;38(3-4):203-10

Is the systemic microvascular endothelial glycocalyx in peritoneal dialysis patients related to peritoneal transport?
Nephron ClinPract. 2014;128(1-2):159-65

Deeper penetration of erythrocytes into the endothelial glycocalyx is associated with impaired microvascular perfusion.
PLoS One. 2014 May 9;9(5):e96477

Skeletal muscle capillary density and microvascular function are compromised with aging and type 2 diabetes.
J ApplPhysiol (1985). 2014 Apr 15;116(8):998-1005 

Microcirculatory effects of the transfusion of leukodepleted or non-leukodepleted red blood cells in patients with sepsis: a pilot study.
Crit Care. 2014 Feb 17;18(1):R33

Association of kidney function with changes in the endothelial surface layer.
Clin J Am SocNephrol. 2014 Apr;9(4):698-704

Alteration of the sublingual microvascular glycocalyx in critically ill patients.
Microvasc Res. 2013 Nov;90:86-9

Non-invasive assessment of microvascular dysfunction in families with premature coronary artery disease.
Int J Cardiol. 2013 Oct 12;168(5):5026-8

Sublingual microvascular glycocalyx dimensions in lacunar stroke patients.
Cerebrovasc Dis. 2013;35(5):451-4

Damage of the endothelial glycocalyx in dialysis patients.
J Am SocNephrol. 2012 Nov;23(11):1900-8

Methods for evaluating endothelial function: a position statement from the European Society of Cardiology Working Group on Peripheral Circulation.
Eur J Cardiovasc PrevRehabil. 2011 Dec;18(6):775-89

Effect of sulodexide on endothelial glycocalyx and vascular permeability in patients with type 2 diabetes mellitus.
Diabetologia. 2010 Dec;53(12):2646-55

Acute ischemic injury to the renal microvasculature in human kidney transplantation.
Am J Physiol Renal Physiol. 2010 Nov;299(5):F1134-40

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